MedLine Search: Bovine Cartilage
This MedLine Search of the technical medical literature is from the early days of CancerGuide so it may not include the latest research. The articles referenced are still relevant but more recent ones may also be available. For more information on the incredibly powerful and freely available MedLine database see my Article on Medline.
In all cases I have selected the references that looked most interesting to me. These are searches with a point of view! There could be references on this same subject that I didn’t include that you would have. For both of these reasons as well as the age of the search, you may want to consider doing your own search on this subject after looking at mine.
Finally, keep in mind that the abstracts presented here are only summaries of the actual articles. If you want to delve deeper you may want to get some of these articles from a Medical Library or an online document delivery service, as is provided with all MedLine accesses (usually for a fairly substantial fee).
SUN MAR 05,1995 4:15 PM PaperChase Contains 8,684,936 References -- All References Found in the Following Databases of the National Library of Medicine and the National Cancer Institute*. You are searching all four databases simultaneously. Database Indexing Began Updated Current through MEDLINE 1966 weekly April 1995 Update, Part 3 HEALTH 1975 monthly March 1995 Update AIDSLINE 1980 monthly December 1994 Update *CANCERLIT 1980 monthly February 1995 Update LIST REFERENCES LIST REFERENCES A) CATRIX 5 C) *SUM AB 17 B) PRUDDEN JF 14 *****PROCEEDINGS OF THE SOCIETY FOR EXPERIMENTAL BIOLOGY AND MEDICINE***** (REFERENCE 1 OF 11) 67044777 Wolarsky ER Finke SR Prudden JF Acceleration of wound healing with heterologous cartilage. Immunological considerations. In: Proc Soc Exp Biol Med (1966 Nov) 123(2):556-61 [No Abstract Available] *****AMERICAN JOURNAL OF SURGERY***** (REFERENCE 2 OF 11) 70176561 Prudden JF Migel P Hanson P Friedrich L Balassa L The discovery of a potent pure chemical wound-healing accelerator. In: Am J Surg (1970 May) 119(5):560-4 [No Abstract Available] (REFERENCE 3 OF 11) 67043403 Allen J Prudden JF Histologic response to a cartilage powder preparation in a controlled human study. In: Am J Surg (1966 Dec) 112(6):888-91 [No Abstract Available] *****JOURNAL OF BIOLOGICAL RESPONSE MODIFIERS***** (REFERENCE 5 OF 11) 89036285 Rosen J Sherman WT Prudden JF Thorbecke GJ Immunoregulatory effects of catrix. In: J Biol Response Mod (1988 Oct) 7(5):498-512 The immunoregulatory effect of Catrix on in vitro and and in vivo antibody production was examined in mice. Catrix, an acidic mucopolysaccharide complex, contains glycosaminoglycans including chondroitin sulfate. Catrix-S, a soluble derivative, was found to enhance T-dependent and T-independent antibody responses in vivo in a dose-dependent manner, with 100 mg intraperitoneally or 10 mg intravenously being optimal. Lower doses were found to be less effective or inhibitory. In vitro, the enhancing activity of Catrix-S on proliferative response was additive with that of dextran sulfate and lipopolysaccharide but not with chondroitin sulfate C. This immunoaugmenting activity appears to be related to the chondroitin sulfate component of Catrix-S, because both have similar effects on in vivo and in vitro antibody responses and because chondroitinase ABC inactivates activity. The inhibitory activity of Catrix-S could be separated from its stimulatory effects by ammonium sulfate precipitation or by fractionation according to molecular weight. The immunoaugmenting effect was present in the 0-30% saturated ammonium sulfate precipitate and in the 5-10,000-m.w. and 30-100,000-m.w. fractions. The ability of Catrix-S to enhance antibody responses in nude as well as in normal mice, and antibody responses to T- independent as well as to T-dependent antigens, indicates that its activity is due in part to a direct effect on B cells and/or to an indirect effect mediated by macrophages. Institutional address: Department of Pathology New York University Medical Center New York. (REFERENCE 6 OF 11) 86114125 Durie BG Soehnlen B Prudden JF Antitumor activity of bovine cartilage extract (Catrix-S) in the human tumor stem cell assay. In: J Biol Response Mod (1985 Dec) 4(6):590-5 Catrix is an acidic mucopolysaccharide complex derived from bovine tracheal cartilage. The antitumor efficacy of Catrix has been evaluated in the human tumor stem cell assay system using three human tumor cell lines and fresh biopsy specimens from 22 patients with malignant tumors. In vitro efficacy has been demonstrated with high dose continuous exposure Catrix, particularly against the 8226 human myeloma cell line as well as ovarian, pancreatic, colon, testicular, and sarcoma biopsy specimens. The level of sensitivity was at less than or equal to 30% survival of colony growth in vitro. Since the in vitro concentrations may be achievable in vivo, the results justify more detailed in vitro evaluation as well as potential clinical trials. Institutional address: Department of Internal Medicine University of Arizona Health Sciences Center Tucson 85724. (REFERENCE 7 OF 11) 86114124 Romano CF Lipton A Harvey HA Simmonds MA Romano PJ Imboden SL A phase II study of Catrix-S in solid tumors. In: J Biol Response Mod (1985 Dec) 4(6):585-9 Catrix-S is an acidic mucopolysaccharide complex derived from bovine tracheal cartilage. This material was administered by weekly subcutaneous injection (5.0-7.5 g/week) to nine patients with progressive metastatic malignancy. One complete response was seen in a patient with metastatic renal cell carcinoma to the lungs. Eight patients had progression of their disease. No undue toxicity and no consistent immunologic alteration was noted. Institutional address: Department of Medicine Milton S. Hershey Medical Center Pennsylvania State University Hershey 17033. (REFERENCE 8 OF 11) 86114123 Prudden JF The treatment of human cancer with agents prepared from bovine cartilage. In: J Biol Response Mod (1985 Dec) 4(6):551-84 Oral and subcutaneous administration of specific preparations of bovine tracheal cartilage rings (Catrix), a nontoxic agent, has resulted in a high response rate in 31 cases of a variety of clinical malignancies (response rate 90%, 61% complete). The demonstrated responder include present therapeutic disasters such as glioblastoma multiforme and cancers of the pancreas and lung. Other types which were treated with success included cancers of the ovary, rectum, prostate, cervix, thyroid, and an inoperable squamous cancer of the nose. These responses were observed when full dose therapy was given over prolonged courses of treatment (years). This wide range of Catrix efficacy now invites investigation by others to confirm the effectiveness of the material and to isolate the molecular entities responsible for these unexpectedly favorable results. Institutional address: Department of Surgery Doctors Hospital New York New York. *****PROCEEDINGS, ANNUAL MEETING OF THE AMERICAN SOCIETY OF CLINICAL***** (REFERENCE 9 OF 11) 94600764 Puccio C Mittelman A Chun H Baskind P Ahmed T Treatment of metastatic renal cell carcinoma with Catrix (Meeting abstract). In: Proc Annu Meet Am Soc Clin Oncol (1994) 13:A769 1994 Catrix is an acidic mucopolysaccharide complex derived from bovine tracheal cartilage which has demonstrated immunostimulatory and anti- mitotic activity in both in vitro and in vivo models. Formulations include an injectable 5% solution and oral capsule 375 mg. Four different schedules were evaluated in patients (pts) with metastatic renal cell carcinoma. Of the 35 pts enrolled, 22 were evaluable for response (completing greater than 3 mo of therapy). Results are shown in a table. Ten of the 22 evaluable pts were not previously treated with any systemic therapy; all 3 responders (and 1 SD) occurred in the subset of untreated pts. Lungs were the major site of response with disappearance of lesions (2) and greater than 50% shrinkage (1); minor responses noted in liver (1) and kidney (1). Duration of response is 30+ mo, 12+ mo and 6+ mo in the 3 PRs. Toxicity was mild (Grade I) and included dysgeusia (8), fatigue (3), dyspepsia (2), nausea (2), fever (2), dizziness (1), and scrotal edema (1). Our results suggest that Catrix is very well tolerated and may be active in previously untreated pts with metastatic renal cell carcinoma. Further accrual of pts is warranted. Institutional address: New York Medical College Valhalla NY 10595 *****SEMINARS IN ARTHRITIS AND RHEUMATISM***** (REFERENCE 10 OF 11) 74168980 Prudden JF Balassa LL The biological activity of bovine cartilage preparations. Clinical demonstration of their potent anti-inflammatory capacity with supplementary notes on certain relevant fundamental supportive studies. In: Semin Arthritis Rheum (1974 Summer) 3(4):287-321 [No Abstract Available] *****SURGERY, GYNECOLOGY AND OBSTETRICS***** (REFERENCE 11 OF 11) 67167476 Prudden JF Wolarsky E The reversal by cartilage of the steroid-induced inhibition of wound healing. In: Surg Gynecol Obstet (1967 Jul) 125(1):109-13 [No Abstract Available]
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